Glycort Eye/ Ear Drops contains Gentamicin, an aminoglycoside antibiotic effective against both gram-positive and gram-negative organisms. Dexamethasone is a very potent and highly selective long-acting glucocorticoid.
Route of Administration
Topical
Composition
Each ml contains:
- Gentamicin as Gentamicin Sulphate I.P. 0.3% w/v
- Dexamethasone 0.1% w/v
- Benzalkonium Chloride Solution (as preservative) I.P. 0.02% v/v
- Sterile aqueous buffered vehicle q.s.
Mechanism of Action
The bactericidal action of gentamicin is based on an irreversible inhibition of the bacterial protein synthesis. Gentamicin elicits rapid bacterial action by acting directly on the bacterial ribosome, where it disrupts the normal cycle of ribosomal function. The corticosteroids are thought to act by controlling the rate of synthesis of proteins important for chemotactic and immunologic reactions.
Indications
Used to treat many types of bacterial infections including conjunctivitis, keratitis, blepharitis, particularly those caused by gram-negative organisms.
Dosage
As directed by the physician.
Directions
Use the solution within one month after opening the container. Do not use it if the solution contains particles/suspended matter.
Side Effects
Eye stinging/burning/redness or temporary blurred vision may occur.
Contraindications
Contraindicated in patients who are hypersensitive to any components of this product.
Drug Interactions
Other drugs, especially those that affect the kidneys, can interact with gentamicin resulting in dangerous side effects and/or decreased effectiveness. Corticosteroids, duloxetine, drugs to treat diabetes, live bacterial vaccines, NSAIDs, probenecid, theophylline, warfarin should be used with caution.
Warning
If irritation persists or increases, discontinue the use and consult the physician. Do not touch the dropper tip to any surface as this may contaminate the solution. Indiscriminate and prolonged use of Glycort may lead to glaucoma, cataract and fungal infections.
Storage
Store in a cool, dry place. Protect from light.
