Mupirocin is a topical antibacterial agent, active against those organisms responsible for the majority of skin infections. It is also active against Gram-negative organisms such as Escherichia coli and Haemophilus influenzae.
Composition
Each g contains:
- Mupirocin I.P. 2.0% w/w
- Non-greasy Base q.s.
Mechanism of Action
Mupirocin is a novel antibiotic produced through fermentation by Pseudomonas fluorescens. Mupirocin inhibits isoleucyl transfer-RNA synthetase, thereby arresting bacterial protein synthesis. Mupirocin has bacteriostatic properties at minimum inhibitory concentrations and bactericidal properties at the higher concentrations reached when applied locally.
Indications
Mupirocin Ointment is used for skin infections, e.g. impetigo, folliculitis, furunculosis.
Direction for Use
Apply gently on the affected area or as directed by the physician.
Contraindications
Hypersensitivity to the active substance(s) or to any of the excipients. This Mupirocin Ointment formulation is not suitable for ophthalmic or intranasal use.
Side Effects
Systemic allergic reactions including anaphylaxis, generalised rash, urticaria and angioedema have been reported with Mupirocin Ointment. Burning localised to the area of application. Itching, erythema, stinging and dryness localised to the area of application. Cutaneous sensitisation reactions to mupirocin or the ointment base.
Precautions
Mupirocin Ointment is not suitable for ophthalmic use, intranasal use (in neonates or infants), used in conjunction with cannulae, at the site of central venous cannulation. Avoid contact with the eyes. If contaminated, the eyes should be thoroughly irrigated with water until the ointment residues have been removed.
Storage
Store at a temperature not exceeding 25°C. Protect from light. Do not freeze.
