Nortor-TZ Tablets contain Norfloxacin is a broad-spectrum antibacterial agent and tinidazole is a synthetic antiprotozoal and antibacterial agent that are used to treat diarrhea and dysentery.
Pharmaceutical Dosage Form:
Tablet
Route of Administration:
Oral
Composition:
Each film-coated tablet contains:
- Norfloxacin I.P. 400 mg
- Tinidazole I.P. 600 mg
- Excipients q.s.
Mechanism of Action:
Norfloxacin is a fluoroquinolone antibiotic. It inhibits bacterial DNA gyrase, an enzyme essential for DNA replication, transcription, repair, and recombination in bacteria. By inhibiting DNA gyrase, Norfloxacin interferes with the process of bacterial DNA synthesis and leads to the death of susceptible bacteria. Tinidazole inhibits the growth of protozoa by interacting with the DNA of the microorganism and inhibiting protein synthesis, thereby leading to the death of the microorganism.
Indications:
Nortor-TZ Tablets are indicated for the treatment of diarrhea and dysentery of amoebic, bacterial, or mixed origins.
Dosage:
As prescribed by the physician.
Storage:
Store at a temperature not exceeding 25°C. Protect from light and moisture.
Presentation:
10 x 4 x 10 Tablets
Side effects:
Dizziness, Nausea, Headache, Abdominal Cramping, Weakness, Fatigue, Malaise, Anorexia, Diarrhea
Contraindications:
In patients with a history of hypersensitivity, tendinitis, or tendon rupture associated with the use of norfloxacin or any member of the quinolone group of antimicrobial and tinidazole or other nitroimidazole derivatives. In pregnancy and during lactation, in patients having, or with a history of, blood dyscrasia, although no persistent hematological abnormalities have been noted in clinical or animal studies.
Drug Interactions:
Nortor-TZ tablets should not be taken with the following medicines due to severe side effects: Caffeine, Clozapine, Ropinirole, Tacrine, Tizanidine, Theophylline, Cyclosporine, Anticoagulants, Glyburide, Probenecid, Nitrofurantoin, Alcohol, Disulfiram, Phenytoin, Fosphenytoin, Cyclosporine, Tacrolimus.
