Torque’s Glimtor M1 Tablets contain Metformin, a biguanide with antihyperglycaemic effects, lowering both basal and postprandial plasma glucose and Glimepiride, a sulphonylurea antihyperglycaemic agent acts mainly by stimulating insulin release from pancreatic beta cells.
Pharmaceutical Dosage Form:
Tablet
Route of Administration:
Oral
Composition:
Each uncoated bilayered tablet contains:
- Metformin Hydrochloride (As Prolonged Release) I.P. 500 mg
- Glimepiride I.P. 1 mg
- Excipients q.s.
Mechanism of Action:
Metformin decreases hepatic glucose production, decreases intestinal absorption of glucose, and improves insulin sensitivity by increasing peripheral glucose uptake and utilization. Glimepiride primarily lowers blood glucose by stimulating the release of insulin from pancreatic beta-cells. It binds to the sulphonylurea receptor in the pancreatic beta-cell plasma membrane, leading to closure of the ATP-sensitive potassium channel, thereby stimulating the release of insulin.
Indications:
Torque’s Glimtor M1 Tablets are indicated for the treatment of patients with type II diabetes mellitus when diet, exercise and a single agent do not result in adequate glycemic control.
Dosage:
As directed by the physician.
Storage:
Store protected from light & moisture, at a temperature not exceeding 30°C.
Presentation:
10 x 15 Tablets
Side effects:
The following adverse reactions may occur: Lactic Acidosis, Taste Disturbance, Nausea, Vomiting, Diarrhoea, Abdominal Pain, Loss of Appetite.
Contraindications:
Torque’s Glimtor M1 Tablets are contraindicated in patients with: Known hypersensitivity to metformin, glimepiride or any of the components of this product. Severe renal impairment, acute or chronic metabolic acidosis, including diabetic ketoacidosis and lactic acidosis, diabetic pre-coma, an allergic reaction to sulphonamide derivatives, hepatic insufficiency, acute alcohol intoxication, alcoholism, and insulin-dependent diabetes.
Drug Interactions:
Alcohol, NSAIDs, ACE Inhibitors, Angiotensin II Receptor Antagonists, Diuretics, Verapamil, Rifampicin, Cimetidine, Dolutegravir, Ranolazine, Trimethoprime, Isavuconazole, Fluconazole, Vandetanib, Crizotinib, Olaparib, Thyroid Stimulating Agents, Glucocorticoids, Anabolic Steroids and Male Sex Hormones.
